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    Faculty - TERI University


    Chaithanya Madhurantakam
    HoD and Associate Professor,
    Department of Biotechnology

    Chaithanya Madhurantakam is a structural biologist and a protein biochemist. He has a Doctoral degree in Biotechnology from the Department of Biotechnology, Indian Institute of Technology (IIT), Kharagpur, India. His research work focuses on structural characterization of proteins through X-ray crystallography. His research work over a period of 15 years include around 7 years of post- doctoral experience (Karolinska Institute, Stockholm; University of Zurich, Zurich and Vrije University, Brussels) covering 18 international peer-reviewed publications, 2 invited book chapters and 3 international publications in proceedings of conference.

    Research Group:
    Chaithanya Madhurantakam (Ramalingaswamy Fellow, DBT- GOI)

    Structural and Molecular Biology Laboratory (SMBL), TU-DBT:

    Researchers at SMBL are involved in deciphering the molecular architecture and intricacies of macromolecules (proteins & nucleic acids) which play crucial role in host immunity, microbial resistance and pathogenicity as well as mammalian allergenic proteins through X-ray crystallography, protein engineering and biochemistry.

    Research Projects:

    1. Structural Studies on Proteins Involved in Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis
    Funding Agency: Department of Biotechnology (DBT), Govt. Of India
    Grant: Ramalingaswamy Re-entry Fellowship

    2. Molecular Characterization of Mammalian Allergens
    Collaborator: Dr. Parveen Goyal, University of Gothenburg, Gothenburg, Sweden

    3. Structural and Biophysical Basis for Biofilm Formation
    Collaborator: Prof. Adnane Achour, Karolinska Institute, Stockholm, Sweden

    4. Structural Studies on Designed Armadillo Repeat Proteins (dArmRPs)
    Collaborators: Prof. Andreas Pluckthun, University of Zurich, Zurich, Switzerland
    Dr. Peer Mittl, University of Zurich, Zurich, Switzerland

    More Information @ www.madhurantakam.com




    Educational Qualifications
    •  Ph D in Biotechnology, Indian Institute of Technology, Kharagpur, 2009

    •  M Sc, Gandhi Institute of Technology and Management (GITAM), Andhra University, 2002

    •  B Sc, Sri Venkateswara University, Tirupati, 2000

    Honors and Awards
    Ramalingaswamy Fellow (DBT, GoI)
    Post Doctoral Fellow- Vrije University, VIB, Brussels, Belgium (2013-2014)
    Post Doctoral Fellow - University of Zurich, Zurich, Switzerland (2010- 2013)
    Post Doctoral Fellow - Karolinska Institute, Stockholm, Sweden (2008 to 2010)
    UGC SRF- University Grants Commission (2007-2008)
    UGC JRF- University Grants Commission (2005-2007)
    Qualified GATE (2004) (Ranked 753)

    Selected Publications
     Structures of designed armadillo repeat proteins binding to peptides fused to globular domains.
    Hansen S, Kiefer JD, Madhurantakam C, Mittl PRE, Pluckthun A.
    Protein Science,

     Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
    Reichen C, Hansen S, Forzani C, Honegger A, Fleishman SJ, Zhou T, Parmeggiani F, Ernst P, Madhurantakam C, Ewald C, Mittl PRE, Zerbe O, Baker D, Caflisch A, Pluckthun A.
    J. Mol. Biol.,

     Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity.
    Hansen S, Tremmel D, Madhurantakam C, Reichen C, Mittl PR, Pluckthun A.
    J Am Chem Soc. 2016 Mar 16;138(10):3526-32. doi: 10.1021/jacs.6b00099. Epub 2016 Mar 2.,

     Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects
    Reichen C, Madhurantakam C, Hansen S, Grutter MG, Pluckthun A, Mittl PR.
    Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):168-75. doi: 10.1107/S2059798315023116. Epub 2016 Jan 1. PMID: 26894544,

     Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct Design and Crystallization Conditions on Overall Structure
    Reichen C, Madhurantakam C, Pluckthun A, Mittl PR.
    Protein Sci. 2014 Aug 13. doi: 10.1002/pro.2535. [Epub ahead of print] PMID: 25132085,


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