ANNOUNCEMENTS
Helicobacter pylori is a spiral-shaped, gram-negative bacteria which grows in the mucus layer that coats the inside of the human stomach. It is a considerable burden to public health; infections acquired in childhood can lead to chronic diseases, including gastric ulcers and cancer. The transmission route of this bacterium is poorly understood, but it generally subsists in water (contaminated) and in poor sanitation conditions. There are no exclusive drugs to eradicate H. pylori, but the multidrug gold-standard treatment achieves eradication rates of over 90%. Healthcare is one objective of the United Nations’ Sustainable Development Goals. Using biotechnological applications, pathogenic organisms and their protein structures can be studied and brought to use in the healthcare of humankind. The GmhC, (also referred to as HldE, D-beta-D-heptose 7-phosphate kinase) is a protein in the lipopolysaccharide (LPS) biosynthesis layer, primarily part of the Heptose synthesis (ADP-d-glycero-β-d-manno-heptose) pathway in H. pylori. The research focuses on blocking the function of this protein, which will truncate the LPS, resulting in control of the growth of H. pylori. The protein has been studied both in vitro and in silico. The purpose of this study was to investigate the molecular interactions of various antimicrobial peptides (AMPs) with H. pylori proteins. This research addresses SDG3, good health, and well-being.
Keywords: Proteins, H. pylori, cancer, antimicrobial peptide, Lipopolysaccharides, control, Heptose synthesis pathway.
